AustralieFrV1, Main, Exploration, bibRecord, 002872

Reversal strategies for vitamin K antagonists in acute intracerebral hemorrhage

Identifieur interne : 002872 ( Main/Exploration ); précédent : 002871; suivant : 002873

Reversal strategies for vitamin K antagonists in acute intracerebral hemorrhage

Auteurs : Adrian R. Parry-Jones ; Mario Di Napoli ; Joshua N. Goldstein ; Floris H. B. M. Schreuder ; Sami Tetri ; Turgut Tatlisumak ; Bernard Yan ; Koen M. Van Nieuwenhuizen ; Nelly Dequatre-Ponchelle ; Matthew Lee-Archer ; Solveig Horstmann ; Duncan Wilson ; Fulvio Pomero ; Luca Masotti ; Christine Lerpiniere ; Daniel Agustin Godoy ; Abigail S. Cohen ; Rik Houben ; Rustam Al-Shahi Salman ; Paolo Pennati ; Luigi Fenoglio ; David Werring ; Roland Veltkamp ; Edith Wood ; Helen M. Dewey ; Charlotte Cordonnier ; Catharina J. M. Klijn ; Fabrizio Meligeni ; Stephen M. Davis ; Juha Huhtakangas ; Julie Staals ; Jonathan Rosand ; Atte Meretoja

Source :

Annals of Neurology [ 0364-5134 ] ; 2015.

RBID : PMC:4654243

Descripteurs français

KwdFr :
- Anticoagulants (effets indésirables), Antifibrinolytiques (usage thérapeutique), Enregistrements, Facteurs de la coagulation sanguine (usage thérapeutique), Femelle, Humains, Hémorragie cérébrale (), Hémorragie cérébrale (mortalité), Modèles de hasards proportionnels, Mâle, Plasma sanguin, Résultat thérapeutique, Sujet âgé, Sujet âgé de 80 ans ou plus, Vitamine K (antagonistes et inhibiteurs), Vitamine K (usage thérapeutique), Études rétrospectives.
MESH :
- antagonistes et inhibiteurs : Vitamine K.
- effets indésirables : Anticoagulants.
- mortalité : Hémorragie cérébrale.
- usage thérapeutique : Antifibrinolytiques, Facteurs de la coagulation sanguine, Vitamine K.
- Enregistrements, Femelle, Humains, Hémorragie cérébrale, Modèles de hasards proportionnels, Mâle, Plasma sanguin, Résultat thérapeutique, Sujet âgé, Sujet âgé de 80 ans ou plus, Études rétrospectives.

English descriptors

KwdEn :
- Aged, Aged, 80 and over, Anticoagulants (adverse effects), Antifibrinolytic Agents (therapeutic use), Blood Coagulation Factors (therapeutic use), Cerebral Hemorrhage (chemically induced), Cerebral Hemorrhage (mortality), Cerebral Hemorrhage (therapy), Female, Humans, Male, Plasma, Proportional Hazards Models, Registries, Retrospective Studies, Treatment Outcome, Vitamin K (antagonists & inhibitors), Vitamin K (therapeutic use).
MESH :
- chemical , adverse effects : Anticoagulants.
- chemical , antagonists & inhibitors : Vitamin K.
- chemical , therapeutic use : Antifibrinolytic Agents, Blood Coagulation Factors, Vitamin K.
- chemically induced : Cerebral Hemorrhage.
- mortality : Cerebral Hemorrhage.
- therapy : Cerebral Hemorrhage.
- Aged, Aged, 80 and over, Female, Humans, Male, Plasma, Proportional Hazards Models, Registries, Retrospective Studies, Treatment Outcome.

Abstract

Objective

There is little evidence to guide treatment strategies for intracerebral hemorrhage on vitamin K antagonists (VKA‐ICH). Treatments utilized in clinical practice include fresh frozen plasma (FFP) and prothrombin complex concentrate (PCC). Our aim was to compare case fatality with different reversal strategies.

Methods

We pooled individual ICH patient data from 16 stroke registries in 9 countries (n = 10 282), of whom 1,797 (17%) were on VKA. After excluding 250 patients with international normalized ratio < 1.3 and/or missing data required for analysis, we compared all‐cause 30‐day case fatality using Cox regression.

Results

We included 1,547 patients treated with FFP (n = 377, 24%), PCC (n = 585, 38%), both (n = 131, 9%), or neither (n = 454, 29%). The crude case fatality and adjusted hazard ratio (HR) were highest with no reversal (61.7%, HR = 2.540, 95% confidence interval [CI] = 1.784–3.616, p < 0.001), followed by FFP alone (45.6%, HR = 1.344, 95% CI = 0.934–1.934, p = 0.112), then PCC alone (37.3%, HR = 1.445, 95% CI = 1.014–2.058, p = 0.041), compared to reversal with both FFP and PCC (27.8%, reference). Outcomes with PCC versus FFP were similar (HR = 1.075, 95% CI = 0.874–1.323, p = 0.492); 4‐factor PCC (n = 441) was associated with higher case fatality compared to 3‐factor PCC (n = 144, HR = 1.441, 95% CI = 1.041–1.995, p = 0.027).

Interpretation

The combination of FFP and PCC might be associated with the lowest case fatality in reversal of VKA‐ICH, and FFP may be equivalent to PCC. Randomized controlled trials with functional outcomes are needed to establish the most effective treatment. Ann Neurol 2015;78:54–62

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4654243

DOI: 10.1002/ana.24416
PubMed: 25857223
PubMed Central: 4654243

Affiliations:

Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Reversal strategies for vitamin <styled-content style="fixed-case">K</styled-content>
 antagonists in acute intracerebral hemorrhage</title>
<author><name sortKey="Parry Ones, Adrian R" sort="Parry Ones, Adrian R" uniqKey="Parry Ones A" first="Adrian R." last="Parry-Jones">Adrian R. Parry-Jones</name>
<affiliation><nlm:aff id="ana24416-aff-0001"></nlm:aff>
</affiliation>
<affiliation><nlm:aff id="ana24416-aff-0002"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Di Napoli, Mario" sort="Di Napoli, Mario" uniqKey="Di Napoli M" first="Mario" last="Di Napoli">Mario Di Napoli</name>
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</affiliation>
<affiliation><nlm:aff id="ana24416-aff-0004"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Goldstein, Joshua N" sort="Goldstein, Joshua N" uniqKey="Goldstein J" first="Joshua N." last="Goldstein">Joshua N. Goldstein</name>
<affiliation><nlm:aff id="ana24416-aff-0005"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Schreuder, Floris H B M" sort="Schreuder, Floris H B M" uniqKey="Schreuder F" first="Floris H. B. M." last="Schreuder">Floris H. B. M. Schreuder</name>
<affiliation><nlm:aff id="ana24416-aff-0006"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Tetri, Sami" sort="Tetri, Sami" uniqKey="Tetri S" first="Sami" last="Tetri">Sami Tetri</name>
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</affiliation>
</author>
<author><name sortKey="Tatlisumak, Turgut" sort="Tatlisumak, Turgut" uniqKey="Tatlisumak T" first="Turgut" last="Tatlisumak">Turgut Tatlisumak</name>
<affiliation><nlm:aff id="ana24416-aff-0008"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Yan, Bernard" sort="Yan, Bernard" uniqKey="Yan B" first="Bernard" last="Yan">Bernard Yan</name>
<affiliation><nlm:aff id="ana24416-aff-0009"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Van Nieuwenhuizen, Koen M" sort="Van Nieuwenhuizen, Koen M" uniqKey="Van Nieuwenhuizen K" first="Koen M." last="Van Nieuwenhuizen">Koen M. Van Nieuwenhuizen</name>
<affiliation><nlm:aff id="ana24416-aff-0010"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Dequatre Onchelle, Nelly" sort="Dequatre Onchelle, Nelly" uniqKey="Dequatre Onchelle N" first="Nelly" last="Dequatre-Ponchelle">Nelly Dequatre-Ponchelle</name>
<affiliation><nlm:aff id="ana24416-aff-0011"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lee Rcher, Matthew" sort="Lee Rcher, Matthew" uniqKey="Lee Rcher M" first="Matthew" last="Lee-Archer">Matthew Lee-Archer</name>
<affiliation><nlm:aff id="ana24416-aff-0012"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Horstmann, Solveig" sort="Horstmann, Solveig" uniqKey="Horstmann S" first="Solveig" last="Horstmann">Solveig Horstmann</name>
<affiliation><nlm:aff id="ana24416-aff-0013"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Wilson, Duncan" sort="Wilson, Duncan" uniqKey="Wilson D" first="Duncan" last="Wilson">Duncan Wilson</name>
<affiliation><nlm:aff id="ana24416-aff-0014"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Pomero, Fulvio" sort="Pomero, Fulvio" uniqKey="Pomero F" first="Fulvio" last="Pomero">Fulvio Pomero</name>
<affiliation><nlm:aff id="ana24416-aff-0015"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Masotti, Luca" sort="Masotti, Luca" uniqKey="Masotti L" first="Luca" last="Masotti">Luca Masotti</name>
<affiliation><nlm:aff id="ana24416-aff-0016"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lerpiniere, Christine" sort="Lerpiniere, Christine" uniqKey="Lerpiniere C" first="Christine" last="Lerpiniere">Christine Lerpiniere</name>
<affiliation><nlm:aff id="ana24416-aff-0017"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Godoy, Daniel Agustin" sort="Godoy, Daniel Agustin" uniqKey="Godoy D" first="Daniel Agustin" last="Godoy">Daniel Agustin Godoy</name>
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</affiliation>
<affiliation><nlm:aff id="ana24416-aff-0019"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Cohen, Abigail S" sort="Cohen, Abigail S" uniqKey="Cohen A" first="Abigail S." last="Cohen">Abigail S. Cohen</name>
<affiliation><nlm:aff id="ana24416-aff-0020"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Houben, Rik" sort="Houben, Rik" uniqKey="Houben R" first="Rik" last="Houben">Rik Houben</name>
<affiliation><nlm:aff id="ana24416-aff-0006"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Al Hahi Salman, Rustam" sort="Al Hahi Salman, Rustam" uniqKey="Al Hahi Salman R" first="Rustam" last="Al-Shahi Salman">Rustam Al-Shahi Salman</name>
<affiliation><nlm:aff id="ana24416-aff-0017"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Pennati, Paolo" sort="Pennati, Paolo" uniqKey="Pennati P" first="Paolo" last="Pennati">Paolo Pennati</name>
<affiliation><nlm:aff id="ana24416-aff-0016"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Fenoglio, Luigi" sort="Fenoglio, Luigi" uniqKey="Fenoglio L" first="Luigi" last="Fenoglio">Luigi Fenoglio</name>
<affiliation><nlm:aff id="ana24416-aff-0015"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Werring, David" sort="Werring, David" uniqKey="Werring D" first="David" last="Werring">David Werring</name>
<affiliation><nlm:aff id="ana24416-aff-0014"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Veltkamp, Roland" sort="Veltkamp, Roland" uniqKey="Veltkamp R" first="Roland" last="Veltkamp">Roland Veltkamp</name>
<affiliation><nlm:aff id="ana24416-aff-0013"></nlm:aff>
</affiliation>
<affiliation><nlm:aff id="ana24416-aff-0021"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Wood, Edith" sort="Wood, Edith" uniqKey="Wood E" first="Edith" last="Wood">Edith Wood</name>
<affiliation><nlm:aff id="ana24416-aff-0002"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Dewey, Helen M" sort="Dewey, Helen M" uniqKey="Dewey H" first="Helen M." last="Dewey">Helen M. Dewey</name>
<affiliation><nlm:aff id="ana24416-aff-0012"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Cordonnier, Charlotte" sort="Cordonnier, Charlotte" uniqKey="Cordonnier C" first="Charlotte" last="Cordonnier">Charlotte Cordonnier</name>
<affiliation><nlm:aff id="ana24416-aff-0011"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Klijn, Catharina J M" sort="Klijn, Catharina J M" uniqKey="Klijn C" first="Catharina J. M." last="Klijn">Catharina J. M. Klijn</name>
<affiliation><nlm:aff id="ana24416-aff-0010"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Meligeni, Fabrizio" sort="Meligeni, Fabrizio" uniqKey="Meligeni F" first="Fabrizio" last="Meligeni">Fabrizio Meligeni</name>
<affiliation><nlm:aff id="ana24416-aff-0022"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Davis, Stephen M" sort="Davis, Stephen M" uniqKey="Davis S" first="Stephen M." last="Davis">Stephen M. Davis</name>
<affiliation><nlm:aff id="ana24416-aff-0009"></nlm:aff>
</affiliation>
<affiliation><nlm:aff id="ana24416-aff-0023"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Huhtakangas, Juha" sort="Huhtakangas, Juha" uniqKey="Huhtakangas J" first="Juha" last="Huhtakangas">Juha Huhtakangas</name>
<affiliation><nlm:aff id="ana24416-aff-0007"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Staals, Julie" sort="Staals, Julie" uniqKey="Staals J" first="Julie" last="Staals">Julie Staals</name>
<affiliation><nlm:aff id="ana24416-aff-0006"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Rosand, Jonathan" sort="Rosand, Jonathan" uniqKey="Rosand J" first="Jonathan" last="Rosand">Jonathan Rosand</name>
<affiliation><nlm:aff id="ana24416-aff-0020"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Meretoja, Atte" sort="Meretoja, Atte" uniqKey="Meretoja A" first="Atte" last="Meretoja">Atte Meretoja</name>
<affiliation><nlm:aff id="ana24416-aff-0008"></nlm:aff>
</affiliation>
<affiliation><nlm:aff id="ana24416-aff-0009"></nlm:aff>
</affiliation>
<affiliation><nlm:aff id="ana24416-aff-0023"></nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">Annals of Neurology</title>
<idno type="ISSN">0364-5134</idno>
<idno type="eISSN">1531-8249</idno>
<imprint><date when="2015">2015</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Aged, 80 and over</term>
<term>Anticoagulants (adverse effects)</term>
<term>Antifibrinolytic Agents (therapeutic use)</term>
<term>Blood Coagulation Factors (therapeutic use)</term>
<term>Cerebral Hemorrhage (chemically induced)</term>
<term>Cerebral Hemorrhage (mortality)</term>
<term>Cerebral Hemorrhage (therapy)</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Plasma</term>
<term>Proportional Hazards Models</term>
<term>Registries</term>
<term>Retrospective Studies</term>
<term>Treatment Outcome</term>
<term>Vitamin K (antagonists & inhibitors)</term>
<term>Vitamin K (therapeutic use)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Anticoagulants (effets indésirables)</term>
<term>Antifibrinolytiques (usage thérapeutique)</term>
<term>Enregistrements</term>
<term>Facteurs de la coagulation sanguine (usage thérapeutique)</term>
<term>Femelle</term>
<term>Humains</term>
<term>Hémorragie cérébrale ()</term>
<term>Hémorragie cérébrale (mortalité)</term>
<term>Modèles de hasards proportionnels</term>
<term>Mâle</term>
<term>Plasma sanguin</term>
<term>Résultat thérapeutique</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Vitamine K (antagonistes et inhibiteurs)</term>
<term>Vitamine K (usage thérapeutique)</term>
<term>Études rétrospectives</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Anticoagulants</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Vitamin K</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antifibrinolytic Agents</term>
<term>Blood Coagulation Factors</term>
<term>Vitamin K</term>
</keywords>
<keywords scheme="MESH" qualifier="antagonistes et inhibiteurs" xml:lang="fr"><term>Vitamine K</term>
</keywords>
<keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Cerebral Hemorrhage</term>
</keywords>
<keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Anticoagulants</term>
</keywords>
<keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Cerebral Hemorrhage</term>
</keywords>
<keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Hémorragie cérébrale</term>
</keywords>
<keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Cerebral Hemorrhage</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antifibrinolytiques</term>
<term>Facteurs de la coagulation sanguine</term>
<term>Vitamine K</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Aged, 80 and over</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Plasma</term>
<term>Proportional Hazards Models</term>
<term>Registries</term>
<term>Retrospective Studies</term>
<term>Treatment Outcome</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Enregistrements</term>
<term>Femelle</term>
<term>Humains</term>
<term>Hémorragie cérébrale</term>
<term>Modèles de hasards proportionnels</term>
<term>Mâle</term>
<term>Plasma sanguin</term>
<term>Résultat thérapeutique</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Études rétrospectives</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec id="ana24416-sec-0001"><title>Objective</title>
<p>There is little evidence to guide treatment strategies for intracerebral hemorrhage on vitamin K antagonists (VKA‐ICH). Treatments utilized in clinical practice include fresh frozen plasma (FFP) and prothrombin complex concentrate (PCC). Our aim was to compare case fatality with different reversal strategies.</p>
</sec>
<sec id="ana24416-sec-0002"><title>Methods</title>
<p>We pooled individual ICH patient data from 16 stroke registries in 9 countries (n = 10 282), of whom 1,797 (17%) were on VKA. After excluding 250 patients with international normalized ratio < 1.3 and/or missing data required for analysis, we compared all‐cause 30‐day case fatality using Cox regression.</p>
</sec>
<sec id="ana24416-sec-0003"><title>Results</title>
<p>We included 1,547 patients treated with FFP (n = 377, 24%), PCC (n = 585, 38%), both (n = 131, 9%), or neither (n = 454, 29%). The crude case fatality and adjusted hazard ratio (HR) were highest with no reversal (61.7%, HR = 2.540, 95% confidence interval [CI] = 1.784–3.616, <italic>p</italic>
 < 0.001), followed by FFP alone (45.6%, HR = 1.344, 95% CI = 0.934–1.934, <italic>p</italic>
 = 0.112), then PCC alone (37.3%, HR = 1.445, 95% CI = 1.014–2.058, <italic>p</italic>
 = 0.041), compared to reversal with both FFP and PCC (27.8%, reference). Outcomes with PCC versus FFP were similar (HR = 1.075, 95% CI = 0.874–1.323, <italic>p</italic>
 = 0.492); 4‐factor PCC (n = 441) was associated with higher case fatality compared to 3‐factor PCC (n = 144, HR = 1.441, 95% CI = 1.041–1.995, <italic>p</italic>
 = 0.027).</p>
</sec>
<sec id="ana24416-sec-0004"><title>Interpretation</title>
<p>The combination of FFP and PCC might be associated with the lowest case fatality in reversal of VKA‐ICH, and FFP may be equivalent to PCC. Randomized controlled trials with functional outcomes are needed to establish the most effective treatment. Ann Neurol 2015;78:54–62</p>
</sec>
</div>
</front>
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</back>
</TEI>
<affiliations><list></list>
<tree><noCountry><name sortKey="Al Hahi Salman, Rustam" sort="Al Hahi Salman, Rustam" uniqKey="Al Hahi Salman R" first="Rustam" last="Al-Shahi Salman">Rustam Al-Shahi Salman</name>
<name sortKey="Cohen, Abigail S" sort="Cohen, Abigail S" uniqKey="Cohen A" first="Abigail S." last="Cohen">Abigail S. Cohen</name>
<name sortKey="Cordonnier, Charlotte" sort="Cordonnier, Charlotte" uniqKey="Cordonnier C" first="Charlotte" last="Cordonnier">Charlotte Cordonnier</name>
<name sortKey="Davis, Stephen M" sort="Davis, Stephen M" uniqKey="Davis S" first="Stephen M." last="Davis">Stephen M. Davis</name>
<name sortKey="Dequatre Onchelle, Nelly" sort="Dequatre Onchelle, Nelly" uniqKey="Dequatre Onchelle N" first="Nelly" last="Dequatre-Ponchelle">Nelly Dequatre-Ponchelle</name>
<name sortKey="Dewey, Helen M" sort="Dewey, Helen M" uniqKey="Dewey H" first="Helen M." last="Dewey">Helen M. Dewey</name>
<name sortKey="Di Napoli, Mario" sort="Di Napoli, Mario" uniqKey="Di Napoli M" first="Mario" last="Di Napoli">Mario Di Napoli</name>
<name sortKey="Fenoglio, Luigi" sort="Fenoglio, Luigi" uniqKey="Fenoglio L" first="Luigi" last="Fenoglio">Luigi Fenoglio</name>
<name sortKey="Godoy, Daniel Agustin" sort="Godoy, Daniel Agustin" uniqKey="Godoy D" first="Daniel Agustin" last="Godoy">Daniel Agustin Godoy</name>
<name sortKey="Goldstein, Joshua N" sort="Goldstein, Joshua N" uniqKey="Goldstein J" first="Joshua N." last="Goldstein">Joshua N. Goldstein</name>
<name sortKey="Horstmann, Solveig" sort="Horstmann, Solveig" uniqKey="Horstmann S" first="Solveig" last="Horstmann">Solveig Horstmann</name>
<name sortKey="Houben, Rik" sort="Houben, Rik" uniqKey="Houben R" first="Rik" last="Houben">Rik Houben</name>
<name sortKey="Huhtakangas, Juha" sort="Huhtakangas, Juha" uniqKey="Huhtakangas J" first="Juha" last="Huhtakangas">Juha Huhtakangas</name>
<name sortKey="Klijn, Catharina J M" sort="Klijn, Catharina J M" uniqKey="Klijn C" first="Catharina J. M." last="Klijn">Catharina J. M. Klijn</name>
<name sortKey="Lee Rcher, Matthew" sort="Lee Rcher, Matthew" uniqKey="Lee Rcher M" first="Matthew" last="Lee-Archer">Matthew Lee-Archer</name>
<name sortKey="Lerpiniere, Christine" sort="Lerpiniere, Christine" uniqKey="Lerpiniere C" first="Christine" last="Lerpiniere">Christine Lerpiniere</name>
<name sortKey="Masotti, Luca" sort="Masotti, Luca" uniqKey="Masotti L" first="Luca" last="Masotti">Luca Masotti</name>
<name sortKey="Meligeni, Fabrizio" sort="Meligeni, Fabrizio" uniqKey="Meligeni F" first="Fabrizio" last="Meligeni">Fabrizio Meligeni</name>
<name sortKey="Meretoja, Atte" sort="Meretoja, Atte" uniqKey="Meretoja A" first="Atte" last="Meretoja">Atte Meretoja</name>
<name sortKey="Parry Ones, Adrian R" sort="Parry Ones, Adrian R" uniqKey="Parry Ones A" first="Adrian R." last="Parry-Jones">Adrian R. Parry-Jones</name>
<name sortKey="Pennati, Paolo" sort="Pennati, Paolo" uniqKey="Pennati P" first="Paolo" last="Pennati">Paolo Pennati</name>
<name sortKey="Pomero, Fulvio" sort="Pomero, Fulvio" uniqKey="Pomero F" first="Fulvio" last="Pomero">Fulvio Pomero</name>
<name sortKey="Rosand, Jonathan" sort="Rosand, Jonathan" uniqKey="Rosand J" first="Jonathan" last="Rosand">Jonathan Rosand</name>
<name sortKey="Schreuder, Floris H B M" sort="Schreuder, Floris H B M" uniqKey="Schreuder F" first="Floris H. B. M." last="Schreuder">Floris H. B. M. Schreuder</name>
<name sortKey="Staals, Julie" sort="Staals, Julie" uniqKey="Staals J" first="Julie" last="Staals">Julie Staals</name>
<name sortKey="Tatlisumak, Turgut" sort="Tatlisumak, Turgut" uniqKey="Tatlisumak T" first="Turgut" last="Tatlisumak">Turgut Tatlisumak</name>
<name sortKey="Tetri, Sami" sort="Tetri, Sami" uniqKey="Tetri S" first="Sami" last="Tetri">Sami Tetri</name>
<name sortKey="Van Nieuwenhuizen, Koen M" sort="Van Nieuwenhuizen, Koen M" uniqKey="Van Nieuwenhuizen K" first="Koen M." last="Van Nieuwenhuizen">Koen M. Van Nieuwenhuizen</name>
<name sortKey="Veltkamp, Roland" sort="Veltkamp, Roland" uniqKey="Veltkamp R" first="Roland" last="Veltkamp">Roland Veltkamp</name>
<name sortKey="Werring, David" sort="Werring, David" uniqKey="Werring D" first="David" last="Werring">David Werring</name>
<name sortKey="Wilson, Duncan" sort="Wilson, Duncan" uniqKey="Wilson D" first="Duncan" last="Wilson">Duncan Wilson</name>
<name sortKey="Wood, Edith" sort="Wood, Edith" uniqKey="Wood E" first="Edith" last="Wood">Edith Wood</name>
<name sortKey="Yan, Bernard" sort="Yan, Bernard" uniqKey="Yan B" first="Bernard" last="Yan">Bernard Yan</name>
</noCountry>
</tree>
</affiliations>
</record>

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Reversal strategies for vitamin K antagonists in acute intracerebral hemorrhage

Reversal strategies for vitamin K antagonists in acute intracerebral hemorrhage

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